Beth Mooney scored a ton as Australia put an England Women's Academy attack to the sword in their three-day tour match in Swindon.
Australia posted 5-360 on day one before declaring with the Academy side facing 14 overs before the end of play and succumbing to 3-49 at close of play.
Most of Australia's batters made starts including Rachael Haynes (47) and Nicole Bolton (41), but it was Mooney (101) and Sophie Molineux (65 not out) who did the bulk of the scoring.
The duo looked comfortable against the English attack, with Molineux's unbeaten 65 coming off just 62 balls and including 10 boundaries.
As has been the case for most of the Ashes thus far, Australia's fast-bowlers got their side off to a great start.
Potential Test debutant Tayla Vlaeminck (2-10) impressed while Ellyse Perry (1-24) was again among the wickets.
Australia holds a six-point Ashes series lead having won the first three One-Day Internationals, with a Test and three Twenty20 Internationals still to be played.
The Ashes is awarded to the team that accrues the most points across the multi-format series, with each ODI and T20 win worth two points, and a Test win worth four points.