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Dethroned Australian Open champion Sofia Kenin has had to have her appendix removed at a Melbourne hospital.

As if losing her Australian Open crown wasn't enough, now Sofia Kenin has had her appendix removed.

Kenin is set for a spell after revealing she had emergency surgery on Monday after first reporting abdominal pain last week.

The world No.4's Open title defence ended with a surprise 6-3 6-2 second-round loss to Kaia Kanepi.

Kenin blamed a failure to handle the pressure for her early exit, before also losing in the second round at this week's Phillip Island Trophy event at Melbourne Park to unranked Australian teenager Olivia Gadecki.

But the 22-year-old's physical condition may also have played a part in her disappointing summer.

"I went to the tournament physician office on Monday, February 15th with acute abdominal pain," Kenin posted on Twitter on Wednesday.

"I was evaluated by the tournament physician and referred to the hospital for further evaluation.

"Acute appendicitis was diagnosed following the completion of my CT scan. I had to have surgery and had my appendix removed on Monday, February 15, at Epworth Hospital Richmond.

"I want to thank everyone at Epworth Hospital Richmond for taking good care of me!"

With Kenin ousted, American eighth seed Danielle Collins and Russian Daria Kasatkina have emerged as the two semi-finalists from the top half of the draw.

Collins thumped Swede Rebecca Peterson 6-1 6-2 in her quarter-final on Wednesday, while Kasatkina upset fourth seed Petra Martic 6-0 6-4.